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Side Effects

Accutane Side Effects

Known complications from Accutane/isotretinoin.

Inflammatory Bowel Disease (IBD)

SEVERE

Crohn's disease and ulcerative colitis developing during or after Accutane treatment.

Depression / Suicidal Thoughts

SEVERE

Psychiatric effects including depression, mood changes, and suicidal ideation.

Birth Defects

SEVERE

Severe birth defects if taken during pregnancy, including heart and brain abnormalities.

Liver Damage

Moderate

Elevated liver enzymes and potential liver toxicity requiring monitoring.

Vision Problems

Moderate

Dry eyes, night blindness, and other visual disturbances.

Joint/Muscle Pain

Common

Myalgia, arthralgia, and decreased bone density.

Severe Dry Skin

Common

Extreme dryness of skin, lips, and mucous membranes.

Hair Thinning

Common

Temporary hair loss or thinning during treatment.

FDA Black Box Warnings

  • • Pregnancy: MUST NOT take if pregnant - severe birth defects
  • • Depression: May cause depression and suicidal thoughts
  • • iPLEDGE: Required registration program for all patients
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